Mutations resulting in the formation of hyperactive complement convertases support cytocidal effect of anti-CD20 immunotherapeutics
Author:
Funder
Narodowe Centrum Nauki
Cancerfonden
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology,Immunology,Immunology and Allergy
Link
http://link.springer.com/article/10.1007/s00262-019-02304-0/fulltext.html
Reference35 articles.
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3. Winiarska M, Glodkowska-Mrowka E, Bil J, Golab J (2010) Molecular mechanisms of the antitumor effects of anti-CD20 antibodies. Front Biosci 16:277–306
4. Kennedy AD, Beum PV, Solga MD, DiLillo DJ, Lindorfer MA, Hess CE, Densmore JJ, Williams ME, Taylor RP (2004) Rituximab infusion promotes rapid complement depletion and acute CD20 loss in chronic lymphocytic leukemia. J Immunol 172:3280–3288
5. Baig NA, Taylor RP, Lindorfer MA, Church AK, LaPlant BR, Pettinger AM, Shanafelt TD, Nowakowski GS, Zent CS (2014) Induced resistance to ofatumumab-mediated cell clearance mechanisms, including complement-dependent cytotoxicity, in chronic lymphocytic leukemia. J Immunol 192:1620–1629. https://doi.org/10.4049/jimmunol.1302954
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