The Role of the Ocular Surface Microbiome (OSM) in Diseases of the Anterior Segment and Ocular Surface
Author:
Publisher
Springer Science and Business Media LLC
Subject
Ophthalmology
Link
https://link.springer.com/content/pdf/10.1007/s40135-022-00294-4.pdf
Reference76 articles.
1. • Doan T, Akileswaran L, Andersen D, Johnson B, Ko N, Shrestha A, et al. Paucibacterial microbiome and resident DNA virome of the healthy conjunctiva. Invest Ophthalmol Vis Sci. 2016;57(13):5116–26. https://doi.org/10.1167/iovs.16-19803. Conjunctival swabs from over 100 healthy volunteers were analyzed by culture, 16S sequencing and biome representational in silico karyotyping, along with swabs from facial skin, buccal mucosa and controls from the environment. The authors found a paucibacterial, distinct conjunctival bacterial community when compared with the facial skin, buccal mucosa and controls.
2. • Ozkan J, Nielsen S, Diez-Vives C, Coroneo M, Thomas T, Willcox M. Temporal stability and composition of the ocular surface microbiome. Sci Rep. 2017;7(1):9880. https://doi.org/10.1038/s41598-017-10494-9. The study identified the composion of the resident ocular surface micrbiome in a healthy population at baseline and then at 1 month and 3 months to asses for change over time. They found that the ocular surface microbiome overall has low diveristy and does not appear to have a core composition, although the microbiome appears specific to an individual.
3. Kang Y, Lin S, Ma X, Che Y, Chen Y, Wan T, et al. Strain heterogeneity, cooccurrence network, taxonomic composition and functional profile of the healthy ocular surface microbiome. Eye Vis (Lond). 2021;8(1):6. https://doi.org/10.1186/s40662-021-00228-4.
4. Matysiak A, Kabza M, Karolak JA, Jaworska MM, Rydzanicz M, Ploski R, et al. Characterization of ocular surface microbial profiles revealed discrepancies between conjunctival and corneal microbiota. Pathogens. 2021;10(4):405. https://doi.org/10.3390/pathogens10040405.
5. Suzuki T, Sutani T, Nakai H, Shirahige K, Kinoshita S. The microbiome of the meibum and ocular surface in healthy subjects. Invest Ophthalmol Vis Sci. 2020;61(2):18. https://doi.org/10.1167/iovs.61.2.18.
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