Affiliation:
1. Department of Medicine, University College London, The Rayne Institute, University Street, London WC1E 6JJ, UK
Abstract
Chlorpromazine, mepacrine, tetracaine, dibucaine, chloroquine, and procaine have been shown to inhibit the iron- and ascorbate-induced lipid peroxidation of skeletal-muscle hornogenates in vitro. These compounds are known to be inhibitors of phospholipase activity, but they were also found to be effective in blocking free-radical-mediated damage to lipids in denatured homogenates, to linoleate suspensions, and to glutamic acid solutions where phospholipase activity was not a relevant factor. The inhibitory action did not appear to be related to any iron-binding activity of the compounds.
Subject
Cell Biology,Molecular Biology,Biochemistry,Biophysics
Cited by
25 articles.
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