A monoclonal antibody against human colonic adenoma recognizes difucosylated Type-2-blood-group chains-Reference-Cited by-同舟云学术

A monoclonal antibody against human colonic adenoma recognizes difucosylated Type-2-blood-group chains

Published:1983-02-01 Issue:2 Volume:3 Page:163-170
ISSN:0144-8463
Container-title:Bioscience Reports
language:en
Short-container-title:

Author:

Brown A.¹,Feizi T.²,Gooi H. C.²,Embleton M. J.¹,Picard J. K.²,Baldwin R. W.¹

Affiliation:

1. Cancer Research Campaign Laboratories, University of Nottingham, University Park, Nottingham NG7 2RD, UK

2. Applied Immunochemistry Research Group, Clinical Research Centre, Watford Road, Harrow, Middlesex HAI 3UJ, UK

Abstract

A monoclonal antibody C14/1/46/10 showing preferential binding to membranes of human colorectal carcinomas over normal colon mucosae was obtained by immunization of mice with extra-nuclear membranes of a human colonic adenoma. Binding and inhibition of binding assays using blood cells or glycoproteins with known blood-group activities indicated that the antibody recognizes a carbohydrate antigen co-existing with the blood-group-H determinant: Fucα1→2Gal. Inhibition assays with structurally defined oligosaccharides showed that the antigenic determinant involves difucosylated Type-2-blood-group chains with the structure:

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Link

https://portlandpress.com/bioscirep/article-pdf/3/2/163/470689/bsr0030163.pdf

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