Binding of benzo[a]pyrene to different chromatin domains following activation at the nuclear membrane-Reference-Cited by-同舟云学术

Binding of benzo[a]pyrene to different chromatin domains following activation at the nuclear membrane

Published:1984-07-01 Issue:7 Volume:4 Page:541-550
ISSN:0144-8463
Container-title:Bioscience Reports
language:en
Short-container-title:

Author:

Obi F. O.¹²,Billett M. A.¹

Affiliation:

1. Department of Biochemistry, University of Nottingham Medical School, Queen's Medical Centre, Nottingham NG7 2UH, UK

2. Department of Biochemistry, College of Medical Sciences, University of Maiduguri, P.M.B. 1069, Maiduguri, Nigeria

Abstract

When isolated liver nuclei from methylchol-anthrene-treated rats are incubated with benzopyrene, covalent adducts are formed between DNA and the ultimate carcinogen, benzopyrene diol epoxide. Brief digestion with DNaseI, or micrococcal nuclease has been used to demonstrate that benzopyrene metabolites bind more readily to DNA in chromatin regions with a more open, active conformation than to inactive chromatin.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Link

https://portlandpress.com/bioscirep/article-pdf/4/7/541/471219/bsr0040541.pdf

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1. Preferential DNA damage in thep53 gene by benzo[a]pyrene metabolites in cytochrome P4501A1-expressing xeroderma pigmentosum group A cells;Molecular Carcinogenesis;1996-05

2. Differential mutagenicity and cytotoxicity of (±)-benzo[a]pyrene-trans-7,8-dihydrodiol and (±)-anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9, 10-epoxide in genetically engineered human fibroblasts;Molecular Carcinogenesis;1995-02

3. Binding of polycyclic and nitropolycyclic aromatic hydrocarbons to specific fractions of rat lung chromatin;Cancer Letters;1989-11

4. Selective repair of methylated purines in regions of chromatin DNA;Carcinogenesis;1986