A novel synthesis and preliminary in vitro cytotoxic evaluation of dihydropyrimidine-2,4(1H, 3 H)-dione derivatives

Author:

UDAYAKUMAR V,GOWSIKA J,PANDURANGAN A

Publisher

Springer Science and Business Media LLC

Subject

General Chemistry

Reference9 articles.

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2. (a) Gibson C L, Huggan J K, Kennedy A, Kiefer L, Lee J H, Suckling C J, Clements C, Harvey A L, Hunter W N and Tulloch L B 2009 Diversity oriented syntheses of fused pyrimidines designed as potential antifolates Org. Biomol. Chem. 7 1829; (b) Sakata K I, Someya M, Matsumoto Y, Tauchi H, Kai M, Toyota M, Takagi M, Hareyama M and Fukushima M 2011 Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination Cancer Sci. 102 1712; (c) Ramesh B and Bhalgat C M 2011 Novel dihydropyrimidines and its pyrazole derivatives: Synthesis and pharmacological screening Eur. J. Med. Chem. 46 1882; (d) Zhu L, Cheng P, Lei N, Yao J, Sheng C, Zhuang C, Guo W, Liu W, Zhang Y, Dong G, Wang S, Miao Z and Zhang W 2011 Synthesis and Biological Evaluation of Novel Homocamptothecins Conjugating with Dihydropyrimidine Derivatives as Potent Topoisomerase I Inhibitors Arch. Pharm. Chem. Life Sci. 344 726; (e) Gangjee A, Zhu Y and Queener S F 1998 6-Substituted 2,4-Diaminopyrido[3,2-d]pyrimidine Analogues of Piritrexim as Inhibitors of Dihydrofolate Reductase from Rat Liver, Pneumocystis carinii, and Toxoplasma gondii and as Antitumor Agents J. Med. Chem. 41 4533

3. (a) Wang X, Lou Q, Guo Y, Xu Y, Zhang Z and Liu J 2006 The design and synthesis of 9-phenylcyclohepta[d]pyrimidine-2,4-dione derivatives as potent non-nucleoside inhibitorsof HIV reverse transcriptase Org. Biomol. Chem. 4 3252; (b) Yachoan R, Mitsuya H, Thomas R V, Pioda J M, Hartman N R, Perno C F, Marczky K S, Allain J P, Johns D G and Broder S 1989 In Vivo Activity Against HIV and Favorable Toxicity Profile of 2 ′,3 ′-Dideoxyinosine Science 245 412; (c) Mellors J W, Im G J, Tramontano E, Winkler S R, Medina D J, Dutschman G E, Bazmi H Z, Piras G, Gonzalez C J and Cheng Y C 1993 A single conservative amino acid substitution in the reverse transcriptase of human immunodeficiency virus-1 confers resistance to (+ )-(5S)-4,5,6,7-tetrahydro-5-methyl-6-(3-methyl-2- butenyl)imidazo[4,5, 1-jk][1,4]benzodiazepin-2(1H)-thione (TIBO R82150) Mol. Pharmacol. 43 11

4. (a) Rashid M, Husain A, Shaharyar M, Mishra R, Hussain A and Afzal O 2014 Design and synthesis of pyrimidine molecules endowed with thiazolidin-4-one as new anticancer agents Eur. J. Med. Chem. 83 630; (b) Lukasik P M, Elabar S, Lam F, Shao H, Liu X, Abbas A Y and Wang S 2012 Synthesis and biological evaluation of imidazo[4,5-b]pyridine and 4-heteroaryl-pyrimidine derivatives as anti-cancer agents Eur. J. Med. Chem. 57 311; (c) Determann R, Dreher J, Baumann K, Preu L, Jones P G, Totzke F, Schachtele C, Kubbutat M H and Kunick C 2012 2-Anilino-4-(benzimidazol-2-yl)pyrimidines – A multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines Eur. J. Med. Chem. 53 254

5. (a) Van den Berg R J B H N, Korevaar C G N, Van der Marel G A, Overkleeft H S and Van Boom J H 2002 A simple and low cost synthesis of d-erythro-sphingosine and d-erythro-azidosphingosine from d-ribo-phytosphingosine: Glycosphingolipid precursors Tetrahedron Lett. 43 8409; (b) Mangfei Y, Qian Z, Jia W, Peng H, Pengfei Y, Rui Z and Dewen D 2016 Triflic Anhydride-Mediated Beckmann Rearrangement Reaction of β-Oximyl Amides: Access to 5-Iminooxazolines J. Chem. Sci. 128 951

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