Deep vein thrombosis
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cardiology and Cardiovascular Medicine
Link
http://link.springer.com/content/pdf/10.1007/s11936-999-0006-8.pdf
Reference50 articles.
1. Brandjes DP, Heijboer H, Buller HR, et al.: Acenocoumarol and heparin compared with acenocoumarol alone in the initial treatment of proximal-vein thrombosis. N Engl J Med 1992, 327:1485–1489.
2. Koopman MMW, Prandoni P, Piovella F, et al.: Treatment of venous thrombosis with intravenous unfractionated heparin administered in the hospital as compared with subcutaneous low-molecular-weight heparin administered at home. N Engl J Med 1996, 334:682–687. In this study, 400 patients with acute proximal deep vein thrombosis were randomly assigned to receive adjusted-dose intravenous unfractionated heparin therapy administered in the hospital or fixed-dose subcutaneous low-molecularweight heparin (LMWH) administered at home. Recurrent thromboembolism and major bleeding developed in 8.6% and 2%, respectively, of patients administered unfractionated heparin and in 6.9% and 2% of those randomized to receive LMWH. LMWH treatment was associated with a mean reduction in hospital stay of 67%, and 36% of patients were never admitted to the hospital.
3. Levine M, Gent M, Hirsh J, et al.: A comparison of lowmolecular-weight heparin administered primarily at home with unfractionated heparin administered in the hospital for proximal deep-vein thrombosis. N Engl J Med 1996, 334:677–681. In this study, 500 patients with acute proximal deep vein thrombosis were randomly assigned to receive either intravenous unfractionated heparin in the hospital or low-molecular-weight heparin (LMWH, twice-daily subcutaneous enoxaparin in a dose of 1 mg/kg) administered primarily at home. Recurrent venous thromboembolism developed in 5.3% of patients administered LMWH compared with 6.7% of those administered unfractionated heparin (P = 0.57). Major bleeding occurred in five patients given LMWH and in three patients randomized to receive unfractionated heparin. Patients administered LMWH spent a mean of 1.1 days in the hospital, compared with 6.5 days for those administered unfractionated heparin.
4. Lagerstedt CI, Olsson CG, Fagher BO, et al.: Need for long-term anticoagulant treatment in symptomatic calf-vein thrombosis. Lancet 1985, 2:515–518.
5. Hull R, Delmore T, Genton E, et al.: Warfarin sodium versus low-dose heparin in the long-term treatment of venous thrombosis. N Engl J Med 1979, 301:855–858.
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