Chlorpromazine and other psychoactive drug induced alterations of a membrane bound enzyme in rat brain

Author:

Nag Maitreyi1,Nandi Namita1

Affiliation:

1. Enzyme Chemistry Department, Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Calcutta 700 032, India

Abstract

Psychoactive drugs like chlorpromazine (CPZ), imipramine, lithium and amphetamine in one way or another affect behaviour. The drug responses are presumably mediated by inducing a change in the activity of membrane bound enzymes. CPZ is very potent in inhibiting the alkaline phosphatase activity in rat brain. The combined effect of CPZ with other drugs shows that CPZ and imipramine together inhibit the enzyme activity significantly greater than the individual inhibition either by CPZ or by imipramine alone. Effective inhibition of the alkaline phosphatase activity with a single drug or combined drugs may lead to a change in neuronal permeability through glucocorticoids thereby affecting mood.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Reference27 articles.

1. Hill, R. T. and Tedeschi, D. H. (1971) In:An Introduction to Psychopharmacology (Rech, R. H., and Moore, K. E., eds.), Raven Press, New York, pp. 238?288.

2. Solow, C. (1971) In:An Introduction to Psychoparmacology (Rech, R. H., and Moore, K. E. eds.), Raven Press, New York, pp. 294?319.

3. Solow, C. (1971) In:An Introduction to Psychoparmacology (Rech, R. H., and Moore, K. E. eds.), Raven Press, New York, pp. 298?319.

4. Barlow, R. B. (1964) In:Introduction to Chemical Parmacology (Inge, H. R., ed.) John Wiley and Sons Inc, New York, pp. 282?288.

5. Weatherall, M. (1968) In:Advances in Pharmacology (Robson, J. M. and Stacey, R. S. eds.), Churchill, London, pp. 1?18.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3