Fate of the Fc fusion protein aflibercept in retinal endothelial cells: competition of recycling and degradation
Author:
Funder
Bayer Vital GmbH
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,Sensory Systems,Ophthalmology
Link
http://link.springer.com/article/10.1007/s00417-018-4166-7/fulltext.html
Reference41 articles.
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2. Do DV, Nguyen QD, Boyer D et al (2012) One-year outcomes of the DA VINCI study of VEGF Trap-eye in eyes with diabetic macular edema. Ophthalmology 119:1658–1665. https://doi.org/10.1016/j.ophtha.2012.02.010
3. Julien S, Biesemeier A, Taubitz T, Schraermeyer U (2014) Different effects of intravitreally injected ranibizumab and aflibercept on retinal and choroidal tissues of monkey eyes. Br J Ophthalmol 98:813–825. https://doi.org/10.1136/bjophthalmol-2013-304019
4. Joo K, Park SJ, Choi Y et al (2017) Role of the Fc region in the vitreous half-life of anti-VEGF drugs. Invest Ophthalmol Vis Sci 58:4261–4267. https://doi.org/10.1167/iovs.17-21813
5. del Amo EM, Rimpelä A-K, Heikkinen E et al (2017) Pharmacokinetic aspects of retinal drug delivery. Prog Retin Eye Res 57:134–185. https://doi.org/10.1016/j.preteyeres.2016.12.001
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