Frailty in the Advanced Heart Failure Patient: A Challenging, Neglected, Yet Potentially Modifiable Risk Factor

Author:

Hsi Brian,Province Valesha,Tang W. H. WilsonORCID

Funder

National Heart, Lung, and Blood Institute

Publisher

Springer Science and Business Media LLC

Subject

Cardiology and Cardiovascular Medicine

Reference43 articles.

1. • Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56:146–156. This study provides a potential standardized definition for frailty in community-dwelling older adults and offers concurrent and predictive validity for the definition.

2. Nadruz W Jr, Kitzman D, Windham BG, Kucharska-Newton A, Butler K, Palta P, et al. Cardiovascular dysfunction and frailty among older adults in the community: the ARIC study. J Gerontol A Biol Sci Med Sci. 2017;72:958–64.

3. • Newman AB, Gottdiener JS, McBurnie MA, Hirsch CH, Kop WJ, Tracy R, et al. Associations of subclinical cardiovascular disease with frailty. J Gerontol A Biol Sci Med Sci. 2001;56:158–166. Cardiovascular disease was associated with an increased likelihood of frail health. In those with no history of CVD, the extent of underlying cardiovascular disease measured by carotid ultrasound and ankle-arm index, LV hypertrophy by ECG and echocardiography, was related to frailty.

4. Moayedi Y, Duero Posada JG, Foroutan F, Goldraich LA, Alba AC, MacIver J, et al. The prognostic significance of frailty compared to peak oxygen consumption and B-type natriuretic peptide in patients with advanced heart failure. Clin Transplant. 2018;32.

5. Lala A, Shah P, Khalatbari S, Yosef M, Mountis MM, Robinson SW, et al. Frailty measures of patient-reported activity and fatigue may predict 1-year outcomes in ambulatory advanced heart failure: a report from the REVIVAL Registry. J Card Fail. 2022;8:765–74.

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