The orphan nuclear receptor Nurr1 agonist amodiaquine mediates neuroprotective effects in 6-OHDA Parkinson’s disease animal model by enhancing the phosphorylation of P38 mitogen-activated kinase but not PI3K/AKT signaling pathway

Author:

Kambey Piniel Alphayo,Chengcheng Ma,Xiaoxiao Guo,Abdulrahman Ayanlaja Abiola,Kanwore Kouminin,Nadeem Iqra,Jiao Wu,Gao DianshuaiORCID

Funder

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,Clinical Neurology,Biochemistry

Reference66 articles.

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2. Aoi M, Date I, Tomita S, Ohmoto T (2000a) The effect of intrastriatal single injection of GDNF on the nigrostriatal dopaminergic system in hemiparkinsonian rats: behavioral and histological studies using two different dosages. Neurosci Res 36(4):319–325. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/10771110. https://doi.org/10.1016/s0168-0102(00)00097-3

3. Aoi M, Date I, Tomita S, Ohmoto T (2000b) Single or continuous injection of glial cell line-derived neurotrophic factor in the striatum induces recovery of the nigrostriatal dopaminergic system. Neurol Res 22(8):832–836. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/11149247. https://doi.org/10.1080/01616412.2000.11740761

4. Bastide MF, Meissner WG, Picconi B, Fasano S, Fernagut PO, Feyder M et al (2015) Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease. Prog Neurobiol 132:96–168. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/26209473. https://doi.org/10.1016/j.pneurobio.2015.07.002

5. Bohush A, Niewiadomska G, Filipek A (2018). Role of mitogen activated protein kinase signaling in Parkinson's disease. Int J Mol Sci, 19(10). Retrieved from ://WOS:000448951000128. https://doi.org/10.3390/ijms19102973

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