Inhibition of the Epigenetic Regulator REST Ameliorates Ischemic Brain Injury
Author:
Funder
National Institutes of Health
Publisher
Springer Science and Business Media LLC
Subject
Neuroscience (miscellaneous),Cellular and Molecular Neuroscience,Neurology
Link
http://link.springer.com/content/pdf/10.1007/s12035-018-1254-y.pdf
Reference52 articles.
1. Hu Z, Zhong B, Tan J, Chen C, Lei Q, Zeng L (2016) The emerging role of epigenetics in cerebral ischemia. Mol Neurobiol 54:1887–1905. https://doi.org/10.1007/s12035-016-9788-3
2. Calderone A, Jover T, Noh KM, Tanaka H, Yokota H, Lin Y, Grooms SY, Regis R et al (2003) Ischemic insults derepress the gene silencer REST in neurons destined to die. J Neurosci 23(6):2112–2121
3. Noh KM, Hwang JY, Follenzi A, Athanasiadou R, Miyawaki T, Greally JM, Bennett MV, Zukin RS (2012) Repressor element-1 silencing transcription factor (REST)-dependent epigenetic remodeling is critical to ischemia-induced neuronal death. Proc Natl Acad Sci U S A 109(16):E962–E971. https://doi.org/10.1073/pnas.1121568109
4. Mehta SL, Kim T, Vemuganti R (2015) Long noncoding RNA FosDT promotes ischemic brain injury by interacting with REST-associated chromatin-modifying proteins. J Neurosci 35(50):16443–16449. https://doi.org/10.1523/jneurosci.2943-15.2015
5. Liu Z, Liu M, Niu G, Cheng Y, Fei J (2009) Genome-wide identification of target genes repressed by the zinc finger transcription factor REST/NRSF in the HEK 293 cell line. Acta Biochim Biophys Sin Shanghai 41(12):1008–1017
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