Glycine Administration Alters MAPK Signaling Pathways and Causes Neuronal Damage in Rat Brain: Putative Mechanisms Involved in the Neurological Dysfunction in Nonketotic Hyperglycinemia

Author:

Moura Alana Pimentel,Parmeggiani Belisa,Gasparotto Juciano,Grings Mateus,Fernandez Cardoso Gabriela Miranda,Seminotti Bianca,Moreira José Cláudio Fonseca,Gelain Daniel Pens,Wajner Moacir,Leipnitz Guilhian

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico (BR) - CNPq

Programa de Apoio a Núcleos de Excelência (PRONEX II)

Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul

Pró-Reitoria de Pesquisa, Universidade Federal do Rio Grande do Sul

Financiadora de Estudos e Projetos - FINEP

Rede Instituto Brasileiro de Neurociência (IBN-Net)

Instituto Nacional de Ciência e Tecnologia em Excitotoxicidade e Neuroproteção (INCT-EN)

Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (BR)

Pró-Reitoria de Pesquisa, Universidade Federal do Rio Grande do Sul (BR)

Financiadora de Estudos e Projetos (BR) - FINEP

Instituto Nacional de Ciência e Tecnologia em Excitotoxicidade e Neuroproteção - INCT-EN

Publisher

Springer Science and Business Media LLC

Subject

Neuroscience (miscellaneous),Cellular and Molecular Neuroscience,Neurology

Reference61 articles.

1. Heindel W, Kugel H, Roth B (1993) Noninvasive detection of increased glycine content by proton MR spectroscopy in the brains of two infants with nonketotic hyperglycinemia. Am J Neuroradiol 14(3):629–635

2. Hamosh A, Johnston MV (2001) Non-ketotic hyperglycinemia. In: Scriver CR, Beaudet A, Sly WS, Valle D (eds) The metabolic and molecular bases of inherited disease, vol editors, 8th edn. McGraw-Hill, New York, pp. 2065–2078

3. Kure S, Korman SH, Kanno J, Narisawa A, Kubota M, Takayanagi T, Takayanagi M, Saito T et al (2006) Rapid diagnosis of glycine encephalopathy by 13C-glycine breath test. Ann Neurol 59(5):862–867. doi: 10.1002/ana.20853

4. Applegarth DA, Toone JR (2006) Glycine encephalopathy (nonketotic hyperglycinemia): comments and speculations. Am J Med Genet A 140(2):186–188. doi: 10.1002/ajmg.a.31030

5. Van Hove J, Coughlin C II, Scharer G (1993) Glycine encephalopathy. In: Pagon RA, Adam MP, Ardinger HH et al. (eds) Gene Reviews (R). Seattle (WA)

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