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Overexpressing lnc240 Rescues Learning and Memory Dysfunction in Hepatic Encephalopathy Through miR-1264-5p/MEF2C Axis

  • Published:2023-01-16 Issue:4 Volume:60 Page:2277-2294
  • ISSN:0893-7648
  • Container-title:Molecular Neurobiology
  • language:en
  • Short-container-title:Mol Neurobiol

Author:

Zhang Huijie,Yu Guangyin,Li Jiong,Tu Chunyi,Hui Yuqing,Liu Danlei,Chen Meiying,Zhang Jifeng,Gong Xiaobing,Guo GuoqingORCID

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province, China

Medical Science and Technology Research Fund of Guangdong province, China

Publisher

Springer Science and Business Media LLC

Subject

Neuroscience (miscellaneous),Cellular and Molecular Neuroscience,Neurology

Reference48 articles.

1. Bayat M, Khalili A, Bayat G, Akbari S, Yousefi Nejad A, Borhani Haghighi A, Haghani M (2022) Effects of platelet-rich plasma on the memory impairment, apoptosis, and hippocampal synaptic plasticity in a rat model of hepatic encephalopathy. Brain Behav 12(1):e2447. https://doi.org/10.1002/brb3.2447

2. Hussien YA, Mansour DF, Nada SA, Abd El-Rahman SS, Abdelsalam RM, Attia AS, El-Tanbouly DM (2022) Linagliptin attenuates thioacetamide-induced hepatic encephalopathy in rats: modulation of C/EBP-β and CX3CL1/Fractalkine, neuro-inflammation, oxidative stress and behavioral defects. Life Sci 295:120378. https://doi.org/10.1016/j.lfs.2022.120378

3. Cabrera-Pastor A, Llansola M, Montoliu C, Malaguarnera M, Balzano T, Taoro-Gonzalez L, García-García R, Mangas-Losada A, Izquierdo-Altarejos P, Arenas YM, Leone P, Felipo V (2019) Peripheral inflammation induces neuroinflammation that alters neurotransmission and cognitive and motor function in hepatic encephalopathy: Underlying mechanisms and therapeutic implications. Acta Physiol (Oxf) 226(2):e13270. https://doi.org/10.1111/apha.13270

4. Weissenborn K, Giewekemeyer K, Heidenreich S, Bokemeyer M, Berding G, Ahl B (2005) Attention, memory, and cognitive function in hepatic encephalopathy. Metab Brain Dis 20(4):359–367. https://doi.org/10.1007/s11011-005-7919-z

5. Khodir AE, Said E (2020) Nifuroxazide attenuates experimentally-induced hepatic encephalopathy and the associated hyperammonemia and cJNK/caspase-8/TRAIL activation in rats. Life Sci 252:117610. https://doi.org/10.1016/j.lfs.2020.117610

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