LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer’s Disease-Reference-Cited by-同舟云学术

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LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer’s Disease

Published:2019-04-19 Issue:10 Volume:56 Page:7234-7245
ISSN:0893-7648
Container-title:Molecular Neurobiology
language:en
Short-container-title:Mol Neurobiol

Author:

Van Gool Bart,Storck Steffen E.,Reekmans Sara M.,Lechat Benoit,Gordts Philip L. S. M.,Pradier Laurent,Pietrzik Claus U.,Roebroek Anton J. M.^ORCID

Funder

Institute for Innovation through Science and Technology in Flanders (IWT-Vlaanderen)

Intramural Funding Program of the University Medical Center of the Johannes Gutenberg University Mainz

American Health Assistance Foundation

Foundation Alzheimer Research

Deutsche Forschungsgemeinschaft

EU Joint Programme – Neurodegenerative Disease Research

Publisher

Springer Science and Business Media LLC

Subject

Neuroscience (miscellaneous),Cellular and Molecular Neuroscience,Neurology

Link

http://link.springer.com/content/pdf/10.1007/s12035-019-1594-2.pdf

Reference42 articles.

1. Mawuenyega KG, Sigurdson W, Ovod V, Munsell L, Kasten T, Morris JC, Yarasheski KE, Bateman RJ (2010) Decreased clearance of CNS beta-amyloid in Alzheimer’s disease. Science 330(6012):1774. https://doi.org/10.1126/science.1197623

2. Da Mesquita S, Louveau A, Vaccari A, Smirnov I, Cornelison RC, Kingsmore KM, Contarino C, Onengut-Gumuscu S et al (2018) Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease. Nature 560(7717):185–191. https://doi.org/10.1038/s41586-018-0368-8

3. Ma Q, Zhao Z, Sagare AP, Wu Y, Wang M, Owens NC, Verghese PB, Herz J et al (2018) Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-beta42 by LRP1-dependent apolipoprotein E isoform-specific mechanism. Mol Neurodegener 13(1):57. https://doi.org/10.1186/s13024-018-0286-0

4. Tarasoff-Conway JM, Carare RO, Osorio RS, Glodzik L, Butler T, Fieremans E, Axel L, Rusinek H et al (2015) Clearance systems in the brain-implications for Alzheimer disease. Nat Rev Neurol 11(8):457–470. https://doi.org/10.1038/nrneurol.2015.119

5. Shinohara M, Tachibana M, Kanekiyo T, Bu G (2017) Role of LRP1 in the pathogenesis of Alzheimer’s disease: Evidence from clinical and preclinical studies. J Lipid Res 58(7):1267–1281. https://doi.org/10.1194/jlr.R075796

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