The Early Activation of PI3K Strongly Enhances the Resistance of Cortical Neurons to Hypoxic Injury via the Activation of Downstream Targets of the PI3K Pathway and the Normalization of the Levels of PARP Activity, ATP, and NAD+-Reference-Cited by-同舟云学术

The Early Activation of PI3K Strongly Enhances the Resistance of Cortical Neurons to Hypoxic Injury via the Activation of Downstream Targets of the PI3K Pathway and the Normalization of the Levels of PARP Activity, ATP, and NAD+

Published:2012-12-20 Issue:2 Volume:47 Page:757-769
ISSN:0893-7648
Container-title:Molecular Neurobiology
language:en
Short-container-title:Mol Neurobiol

Author:

Noh Min Young,Kim Young Seo,Lee Kyu-Yong,Lee Young Joo,Kim Seung H.,Yu Hyun-Jeung,Koh Seong-Ho

Publisher

Springer Science and Business Media LLC

Subject

Neuroscience (miscellaneous),Cellular and Molecular Neuroscience,Neurology

Link

http://link.springer.com/content/pdf/10.1007/s12035-012-8382-6.pdf

Reference56 articles.

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3. Banasiak KJ, Xia Y, Haddad GG (2000) Mechanisms underlying hypoxia-induced neuronal apoptosis. Prog Neurobiol 62:215–49

4. Alvarez-Tejado M, Naranjo-Suarez S, Jimenez C, Carrera AC, Landazuri MO, del Peso L (2001) Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. J Biol Chem 276:22368–74. doi: 10.1074/jbc.M011688200

5. Zhang SX, Gozal D, Sachleben LR, Rane M Jr, Klein JB, Gozal E (2003) Hypoxia induces an autocrine-paracrine survival pathway via platelet-derived growth factor (PDGF)-B/PDGF-beta receptor/phosphatidylinositol 3-kinase/Akt signaling in RN46A neuronal cells. FASEB journal: official publication of the Federation of American Societies for Experimental Biology 17:1709–11. doi: 10.1096/fj.02-1111fje

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