4-Octyl itaconate alleviates dextran sulfate sodium-induced ulcerative colitis in mice via activating the KEAP1-NRF2 pathway

Author:

Wang Yujin,Zhao Xue,Gao Yifei,Zhao Chenxi,Li Jingxin,Wang Shuanglian,Xue Bing,Liu Chuanyong,Ma XuelianORCID

Funder

National Natural Science Foundation of China

Shandong Provincial Natural Science Foundation

Publisher

Springer Science and Business Media LLC

Reference47 articles.

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3. Bel S, Elkis Y, Lerer-Goldstein T, Nyska A, Shpungin S, Nir U (2012) Loss of TMF/ARA160 protein renders colonic mucus refractory to bacterial colonization and diminishes intestinal susceptibility to acute colitis. J Biol Chem 287(30):25631–25639. https://doi.org/10.1074/jbc.M112.364786

4. Burri E, Maillard MH, Schoepfer AM, Seibold F, Van Assche G, Riviere P, Laharie D, Manz M, Swiss Ibdnetaowgot SSoG (2020) Treatment algorithm for mild and moderate-to-severe ulcerative colitis: an update. Digestion 101(Suppl 1):2–15. https://doi.org/10.1159/000504092

5. Cai C, Ma H, Peng J, Shen X, Zhen X, Yu C, Zhang P, Ji F, Wang J (2023) USP25 regulates KEAP1-NRF2 anti-oxidation axis and its inactivation protects acetaminophen-induced liver injury in male mice. Nat Commun 14(1):3648. https://doi.org/10.1038/s41467-023-39412-6

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