Tryptophan metabolism and its relationship with central nervous system toxicity in people living with HIV switching from efavirenz to dolutegravir

Author:

Keegan Michael R.ORCID,Winston Alan,Higgs Chris,Fuchs Dietmar,Boasso Adriano,Nelson Mark

Funder

ViiV Healthcare

Publisher

Springer Science and Business Media LLC

Subject

Virology,Cellular and Molecular Neuroscience,Clinical Neurology,Neurology

Reference39 articles.

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2. Badawy AAB, Dougherty DM (2016) Assessment of the human kynurenine pathway: comparisons and clinical implications of ethnic and gender differences in plasma tryptophan, kynurenine metabolites, and enzyme expressions at baseline and after acute tryptophan loading and depletion. Int J Tryptophan Res 9:31–49

3. Baran H, Hainfellner JA, Kepplinger B, Mazal PR, Schmid H, Budka H (2000) Kynurenic acid metabolism in the brain of HIV-1 infected patients. J Neural Transm 107(10):1127–1138

4. Boasso A, Shearer GM (2007) How does indoleamine 2,3-dioxygenase contribute to HIV-mediated immune dysregulation. Curr Drug Metab 8:217–223

5. Bracchi M, Pagani N, Clarke A, Adams T, Waters L, Bolton M, et al (n.d.) Multicentre open-label pilot study of switching from efavirenz to dolutegravir for central nervous system toxicity. International Congress of Drug Therapy in HIV Infection 23-26 October 2016, Glasgow, UK, p 209

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