Abstract
AbstractTemperature fluctuation is one of the most frequent threats to which organisms are exposed in nature. The activation of gene expression programs that trigger the transcription of heat stress-protective genes is the main cellular response to resist high temperatures. In addition, reversible accumulation and compartmentalization of thermosensitive proteins in high-order molecular assemblies are emerging as critical mechanisms to ensure cellular protection upon heat stress. Here, we summarize representative examples of membrane-less intracellular bodies formed upon heat stress in yeasts and human cells and highlight how protein aggregation can be turned into a cytoprotective mechanism.
Funder
Ministerio de Ciencia, Innovación y Universidades
Junta de Andalucia-FEDER-UPO
Publisher
Springer Science and Business Media LLC
Subject
Genetics,General Medicine
Cited by
13 articles.
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