Author:
Aichane Khadija,Windheim Mark
Abstract
AbstractHuman adenoviruses have evolved mechanisms of immune evasion to counteract antiviral measures. The E3/49K protein of species D adenoviruses and its secreted form sec49K trigger dimerization of the receptor-like tyrosine phosphatase CD45, thereby inhibiting the activation of immune cells. Intriguingly, the design of the membrane-anchored E3/49K resembles a fishing rod with an extended disordered region used as a fishing line and two N-terminal domains as baits to optimize binding to CD45.
Publisher
Springer Science and Business Media LLC
Subject
Molecular Biology,Biotechnology
Reference10 articles.
1. Wold WSM, Ison MG (2013) Adenoviruses. In: Fields Virology, Sixth ed. Knipe DM, Howley PM (Hrsg). Lippincott Williams & Wilkins, Philadelphia, 1732–1767
2. Windheim M, Hilgendorf A, Burgert HG (2004) Immune evasion by adenovirus E3 proteins: Exploitation of intracellular trafficking pathways. Curr Top Microbiol Immunol 273: 29–85
3. Blusch JH, Deryckere F, Windheim M et al. (2002) The novel early region 3 protein E3/49K is specifically expressed by adenoviruses of subgenus D: Implications for epidemic keratoconjunctivitis and adenovirus evolution. Virology 296: 94–106
4. Deryckere F, Burgert HG (1996) Early region 3 of adenovirus type 19 (subgroup D) encodes an HLA-binding protein distinct from that of subgroups B and C. J Virol 70: 2832–2841
5. Windheim M, Burgert HG (2002) Characterization of E3/49K, a novel, highly glycosylated E3 protein of the epidemic keratoconjunctivitis-causing adenovirus type 19a. J Virol 76: 755–766