Chlamydien als Risikofaktoren für Eierstock- und Gebärmutterhalskrebs

Author:

Vollmuth Nadine,Rudel Thomas

Abstract

AbstractEpidemiological studies provide the first indications of a connection between cervical and ovarian cancer and infections with Chlamydia trachomatis. Chlamydia is the most common bacterial cause of sexually transmitted diseases. These obligate intracellular bacteria manipulate their host cells to support progeny formation. In this article, we present possible mechanisms that allow the bacteria to survive in the host cell, but at the same time may contribute to the development of cancer.

Publisher

Springer Science and Business Media LLC

Subject

Molecular Biology,Biotechnology

Reference13 articles.

1. Arcia Franchini AP, Iskander B, Anwer F, et al. (2022) The Role of Chlamydia Trachomatis in the Pathogenesis of Cervical Cancer. Cureus 14:e21331

2. Bhuvanendran Pillai A, Mun Wong C, Dalila Inche Zainal Abidin N, et al. (2022) Chlamydia Infection as a Risk Factor for Cervical Cancer: A Systematic Review and Meta-Analysis. Iran J Public Health 51:508–517

3. Carvalho JP, Carvalho FM (2008) Is Chlamydia-infected tubal fimbria the origin of ovarian cancer?. Med Hypotheses 71:690–693

4. Chumduri C, Gurumurthy RK, Zadora PK, et al. (2013) Chlamydia infection promotes host DNA damage and proliferation but impairs the DNA damage response. Cell Host Microbe 13:746–758

5. González E, Rother M, Kerr MC, et al. (2014) Chlamydia infection depends on a functional MDM2-p53 axis. Nat Commun 5:5201

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