Signalschalter an der mitochondrialen Importmaschinerie

Abstract

AbstractThe mitochondrial protein import machineries were anticipated to be constitutively active entities enabling continuous protein influx. However, recent studies revealed that the main protein entry gate at the outer membrane, the TOM complex, is targeted by several cytosolic signalling cascades and that activated protein kinases can directly modulate biogenesis, assembly and function of the import machinery. This enables a dynamic adaptation of the mitochondrial proteome to changing cellular demands.