Einsatz von T-Zelltherapien in der soliden Onkologie

Abstract

AbstractLately, cellular immunotherapies have emerged as a powerful tool in treating hematological malignancies. However, these therapeutic advances have not demonstrated sustained efficacy in solid oncology yet. The reasons are multi-layered and can be brought down to the missing antigen specificity, lack of immune cell infiltration into the tumor and the hostile tumor microenvironment, rendering immune cells dysfunctional. Here, we give an overview of current problems and solutions for cellular immunotherapies in solid tumors.