Molekulare Schnappschüsse der Phageninfektion

Abstract

AbstractToday, the clinical potential of antibiotics is almost exhausted, which has led to a renaissance of phage research and phage therapy. To maximize phage therapy efficiency, we need an in-depth understanding of the molecular mechanisms by which phages fight their hosts. Omics technologies can provide valuable insights in the molecular processes of infection. We applied time-resolved proteomics and transcriptomics to characterize the T4 phage infection of Escherichia coli on the molecular level.