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New Molecular Considerations for Glioma: IDH, ATRX, BRAF, TERT, H3 K27M

  • Published:2017-02 Issue:2 Volume:17 Page:
  • ISSN:1528-4042
  • Container-title:Current Neurology and Neuroscience Reports
  • language:en
  • Short-container-title:Curr Neurol Neurosci Rep

Author:

Karsy Michael,Guan Jian,Cohen Adam L.,Jensen Randy L.,Colman Howard

Publisher

Springer Science and Business Media LLC

Subject

Neurology (clinical),General Neuroscience

Reference126 articles.

1. • Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 2016;131(6):803–20. doi: 10.1007/s00401-016-1545-1 . This summary reviews the major changes to the 2016 WHO classification of tumors of the central nervous system and places new emphasis on the use of molecular information to classify gliomas.

2. Coons SW, Johnson PC, Scheithauer BW, Yates AJ, Pearl DK. Improving diagnostic accuracy and interobserver concordance in the classification and grading of primary gliomas. Cancer. 1997;79(7):1381–93.

3. Ohgaki H, Kleihues P. The definition of primary and secondary glioblastoma. Clin Cancer Res. 2013;19(4):764–72. doi: 10.1158/1078-0432.CCR-12-3002 .

4. • Brat DJ, Verhaak RG, Aldape KD, Yung WK, Salama SR, Cooper LA, et al. Comprehensive, integrative genomic analysis of diffuse lower-grade gliomas. N Engl J Med. 2015;372(26):2481–98. doi: 10.1056/NEJMoa1402121 . This study performed multi-platform sequencing of 293 LGG delineating mutational subtypes based on IDH, 1p/19q, and p53 status.

5. • Ceccarelli M, Barthel FP, Malta TM, Sabedot TS, Salama SR, Murray BA, et al. Molecular profiling reveals biologically discrete subsets and pathways of progression in diffuse glioma. Cell. 2016;164(3):550–63. doi: 10.1016/j.cell.2015.12.028 . This study evaluated 1,122 diffuse gliomas showing the importance of ATRX and TERT in telomere maintenance of gliomas, as well as subtypes of IDH-mutant gliomas with poor prognosis versus subtypes of IDH-wild-type gliomas with good prognosis.

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