Advances in clinical trials for amyotrophic lateral sclerosis

Author:

Gordon Paul H.

Publisher

Springer Science and Business Media LLC

Subject

Neurology (clinical),General Neuroscience

Reference39 articles.

1. Pascuzzi RM: Blinded and seeing the light, (John Noseworthy), Lou Gehrig and other tales of enlightenment. Semin Neurol 1998, 18:415–418.

2. Rowland LP, Shneider NA: Amyotrophic lateral sclerosis. N Engl J Med 2001, 344:1688–1700.

3. Young FE, Norris JA, Levitt JA, Nightingale SL: The FDA’s new procedures for the use of investigational drugs in treatment. JAMA 1988, 25:2267–2270.

4. Cedarbaum JM, Stambler N: Disease status and use of ventilatory support by ALS patients. BDNF Study Group. Amyotroph Lateral Scler Other Motor Neuron Disord 2001, 2:19–22.

5. Miller RG, Mitchell JD, Lyon M, Moore DH: Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND). Cochrane Neuromuscular Disease Group. Cochrane Database of Systematic Reviews 2004, 2. This work uses a meta-analysis to analyze the data of three reported randomized trials of a total of 876 patients examining the efficacy of riluzole in ALS. The results indicate that riluzole treatment extends survival by about 2 months.

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