Moving the Dial Toward Equity in Parkinson’s Disease Clinical Research: a Review of Current Literature and Future Directions in Diversifying PD Clinical Trial Participation

Author:

Adrissi JenniferORCID,Fleisher JoriORCID

Publisher

Springer Science and Business Media LLC

Subject

Neurology (clinical),General Neuroscience

Reference65 articles.

1. Nussbaum RL, Ellis CE. Alzheimer’s disease and Parkinson’s disease. N Engl J Med. 2003;348(14):1356–64.

2. Dorsey ER, et al. The emerging evidence of the Parkinson pandemic. J Parkinsons Dis. 2018;8(s1):S3–8.

3. Vespa J, Medina L, Armstrong D. Demographic turning points for the United States: population projections for 2020 to 2060 population estimates and projections. In: Current Population Reports. Washington DC: US Census Bureau; 2020. p. 1–15.

4. Caplan A, Friesen P. Health disparities and clinical trial recruitment: is there a duty to tweet? PLoS Biol. 2017;15(3):e2002040.

5. Lau YH, et al. Does ethnicity influence recruitment into clinical trials of Parkinson’s disease? J Parkinsons Dis. 2022. A systematic search of PD trials between 2017 and 2021 on the clinicaltrials.gov database revealed that only 42.65% of the 57 trials published in peer-reviewed journals reported participant racial distribution. Of these, only 5 studies had mixed racial representation and only 2 had Black research participants—supporting the need for increased reporting and recruitment of racial diversity in PD clinical trials.

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