Understanding Essential Tremor: Progress on the Biological Front
Author:
Publisher
Springer Science and Business Media LLC
Subject
Neurology (clinical),General Neuroscience
Link
http://link.springer.com/content/pdf/10.1007/s11910-014-0450-z.pdf
Reference99 articles.
1. Louis ED, Ferreira JJ. How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor. Mov Disord. 2010;25(5):534–41.
2. Benito-León J, Bermejo-Pareja F, Morales JM, Vega S, Molina JA. Prevalence of essential tremor in three elderly populations of central Spain. Mov Disord. 2003;18(4):389–94.
3. Hardesty DE, Maraganore DM, Matsumoto JY, Louis ED. Increased risk of head tremor in women with essential tremor: longitudinal data from the Rochester Epidemiology Project. Mov Disord. 2004;19(5):529–33.
4. Louis ED, Rios E, Applegate LM, Hernandez NC, Andrews HF. Jaw tremor: prevalence and clinical correlates in three essential tremor case samples. Mov Disord. 2006;21(11):1872–8.
5. Gitchel GT, Wetzel PA, Baron MS. Slowed saccades and increased square wave jerks in essential tremor. Tremor Other Hyperkinet Mov (N Y). 2013;3. http://tremorjournal.org/article/view/178 . Sixty ET patients and 60 age-matched controls were studied using a video-based eye tracker to assess binocular eye position. Oculomotor function was assessed while subjects followed random horizontally and vertically step-displaced targets. In contrast to normally swift onset and efficient acceleration/deceleration movements, saccades in ET patients were characterized by abnormally prolonged latencies and slowed velocity profiles. This study demonstrated the presence of novel oculomotor deficits in patients with ET, which are distinct from the eye movement dysfunctions of other movement disorders. The findings support a role of cerebellar dysfunction in disease pathogenesis.
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