Exploring the Role of Locus Coeruleus in Alzheimer’s Disease: a Comprehensive Update on MRI Studies and Implications-Reference-Cited by-同舟云学术

Exploring the Role of Locus Coeruleus in Alzheimer’s Disease: a Comprehensive Update on MRI Studies and Implications

Published:2023-12 Issue:12 Volume:23 Page:925-936
ISSN:1528-4042
Container-title:Current Neurology and Neuroscience Reports
language:en
Short-container-title:Curr Neurol Neurosci Rep

Author:

Galgani Alessandro,Giorgi Filippo Sean

Abstract

Abstract Purpose of Review Performing a thorough review of magnetic resonance imaging (MRI) studies assessing locus coeruleus (LC) integrity in ageing and Alzheimer’s disease (AD), and contextualizing them with current preclinical and neuropathological literature. Recent Findings MRI successfully detected LC alterations in ageing and AD, identifying degenerative phenomena involving this nucleus even in the prodromal stages of the disorder. The degree of LC disruption was also associated with the severity of AD cortical pathology, cognitive and behavioral impairment, and the risk of clinical progression. Summary Locus coeruleus-MRI has proved to be a useful tool to assess the integrity of the central noradrenergic system in vivo in humans. It allowed to test in patients preclinical and experimental hypothesis, thus confirming the specific and marked involvement of the LC in AD and its key pathogenetic role. Locus coeruleus-MRI–related data might represent the theoretical basis on which to start developing noradrenergic drugs to target AD.

Funder

Università di Pisa

Publisher

Springer Science and Business Media LLC

Subject

Neurology (clinical),General Neuroscience

Link

https://link.springer.com/content/pdf/10.1007/s11910-023-01324-9.pdf

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