Pharmacokinetics and Safety of Single and Multiple Doses of Oral N-Acetylcysteine in Healthy Chinese and Caucasian Volunteers: An Open-Label, Phase I Clinical Study-Reference-Cited by-同舟云学术

Pharmacokinetics and Safety of Single and Multiple Doses of Oral N-Acetylcysteine in Healthy Chinese and Caucasian Volunteers: An Open-Label, Phase I Clinical Study

Published:2020-11-04 Issue:1 Volume:38 Page:468-478
ISSN:0741-238X
Container-title:Advances in Therapy
language:en
Short-container-title:Adv Ther

Author:

Papi Alberto,Di Stefano Andrea F. D.^ORCID,Radicioni Milko

Funder

Zambon S.p.A., Italy.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),General Medicine

Link

http://link.springer.com/content/pdf/10.1007/s12325-020-01542-4.pdf

Reference13 articles.

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2. Sies H. Glutathione and its role in cellular functions. Free Radic Biol Med. 1999;27(9–10):916–21. https://doi.org/10.1016/s0891-5849(99)00177-x.

3. Rodenstein D, DeCoster A, Gazzaniga A. Pharmacokinetics of oral acetylcysteine: absorption, binding and metabolism in patients with respiratory disorders. Clin Pharmacokinet. 1978;3(3):247–54. https://doi.org/10.2165/00003088-197803030-00005.

4. Borgstrom L, Kagedal B, Paulsen O. Pharmacokinetics of N-acetylcysteine in man. Eur J Clin Pharmacol. 1986;31(2):217–22. https://doi.org/10.1007/bf00606662.

5. Olsson B, Johansson M, Gabrielsson J, Bolme P. Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine. Eur J Clin Pharmacol. 1988;34(1):77–82. https://doi.org/10.1007/bf01061422.

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