Efficacy of Lomitapide in the Treatment of Familial Homozygous Hypercholesterolemia: Results of a Real-World Clinical Experience in Italy

Author:

D’Erasmo LauraORCID,Cefalù Angelo Baldassare,Noto Davide,Giammanco Antonina,Averna Maurizio,Pintus Paolo,Medde Paolo,Vigna Giovanni Battista,Sirtori Cesare,Calabresi Laura,Pavanello Chiara,Bucci Marco,Sabbà Carlo,Suppressa Patrizia,Natale Francesco,Calabrò Paolo,Sampietro Tiziana,Bigazzi Federico,Sbrana Francesco,Bonomo Katia,Sileo Fulvio,Arca Marcello

Funder

Italian Ministry of Education, University and Research

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),General Medicine

Reference34 articles.

1. Cuchel M, Bruckert E, Ginsberg HN, et al. Homozygous familial hypercholesterolaemia: new insights and guidance for physicians to improve detection and clinical management. A position paper from the consensus panel on familial hypercholesterolaemia of the European Atherosclerosis Society. Eur Heart J. 2015;35:2146e57.

2. Goldstein JL, Hobbs HH, Brown MS. Familial hypercholesterolemia. In: Scriver C, Beaudet A, Sly W, Valle D, editors. The metabolic and molecular bases of inherited disease. 8th ed. New York: McGraw-Hill; 2001. p. 2863–913.

3. Sjouke B, Kusters DM, Kindt I, et al. Homozygous autosomal dominant hypercholesterolaemia in the Netherlands: prevalence, genotype phenotype relationship, and clinical outcome. Eur Heart J. 2015;36:560–5.

4. Santos RD, Gidding SS, Hegele RA, et al. Defining severe familial hypercholesterolaemia and the implications for clinical management: a consensus statement from the International Atherosclerosis Society Severe Familial Hypercholesterolemia Panel. Lancet Diabetes Endocrinol. 2016. (pii: S2213-8587(16)30041-9).

5. Sniderman AD, Tsimikas S, Fazio S. The severe hypercholesterolemia phenotype: clinical diagnosis, management, and emerging therapies. J Am Coll Cardiol. 2014;63(19):1935–47.

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