Biosimilar Pegfilgrastim-cbqv Demonstrated Similar Immunogenicity to Pegfilgrastim in Healthy Subjects Across Three Randomized Clinical Studies

Author:

Civoli FrancescaORCID,Finck BarbaraORCID,Tang Helen,Hodge Jennifer,O’Kelly Hillary,Vexler Vladimir

Funder

Coherus BioSciences, Inc.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),General Medicine

Reference18 articles.

1. European Medicines Agency. Guideline on similar biological medicinal products containing biotechnology-derived proteins as active substance: non-clinical and clinical issues. Published December 18, 2014. Accessed 20 Oct 2021. https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-similar-biological-medicinal-products-containing-biotechnology-derived-proteins-active_en-2.pdf.

2. US Food and Drug Administration. Guidance for Industry. Scientific considerations in demonstrating biosimilarity to a reference product. Published April 2015. Accessed 20 Oct 2021. https://www.fda.gov/media/82647/download.

3. European Medicines Agency. Biosimilars in the EU. Information guide for healthcare professionals. Accessed 20 Oct 2021. https://www.ema.europa.eu/en/documents/leaflet/biosimilars-eu-information-guide-healthcare-professionals_en.pdf.

4. US Food and Drug Administration. Clinical pharmacology data to support a demonstration of biosimilarity to a reference product. Published December 2016. Accessed 20 Oct 2021. https://www.fda.gov/regulatory-information/search-fda-guidance-documents/clinical-pharmacology-data-support-demonstration-biosimilarity-reference-product.

5. Wolff-Holz E, Tiitso K, Vleminckx C, Weise M. Evolution of the EU biosimilar framework: past and future. BioDrugs. 2019;33(6):621–34.

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