Abstract
AbstractThe Brugada syndrome (BrS) is a cardiac arrhythmic disorder responsible for sudden cardiac death associated with the onset of ventricular arrhythmias, such as reentrant ventricular tachycardia and fibrillation. The mechanisms which lead to the onset of such electrical disorders in patients affected by BrS are not completely understood, yet. The aim of the present study is to investigate by means of numerical simulations the electrophysiological mechanisms at the basis of the morphology of electrocardiogram (ECG) and the onset of reentry associated with BrS. To this end, we consider the Bidomain equations coupled with the ten Tusscher–Panfilov membrane model, on an idealized wedge of human right ventricular tissue. The results have shown that: (1) epicardial dispersion of repolarization, generated by the coexistence of regions of early and late repolarization, due to different modulation of the $$I_\mathrm{{CaL}}$$
I
CaL
current, produces ECG waveforms exhibiting qualitatively the typical BrS morphology, characterized by ST elevation and partially negative T-waves; (2) epicardial dispersion of repolarization promotes the onset of reentry during the implementation of the programmed stimulation protocol, because of the conduction block occurring when a premature beat reaches the border of late repolarizing regions; and (3) the modulation of the $$I_\mathrm{{to}}$$
I
to
current affects the duration of reentry, which becomes sustained with a remarkable increase of $$I_\mathrm{{to}}$$
I
to
in the subepicardial layers.
Funder
Ministero dell’Istruzione, dell’Università e della Ricerca
European High-Performance Computing Joint Undertaking EuroHPC
Publisher
Springer Science and Business Media LLC
Subject
Computational Theory and Mathematics,General Agricultural and Biological Sciences,Pharmacology,General Environmental Science,General Biochemistry, Genetics and Molecular Biology,General Mathematics,Immunology,General Neuroscience
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献