Modeling the Effects of Latency Reversing Drugs During HIV-1 and SIV Brain Infection with Implications for the “Shock and Kill” Strategy

Author:

Roda Weston C.ORCID,Liu Suli,Power Christopher,Li Michael Y.

Funder

National Science and Engineering Research Council of Canada

Canada Foundation for Innovation

Publisher

Springer Science and Business Media LLC

Subject

Computational Theory and Mathematics,General Agricultural and Biological Sciences,Pharmacology,General Environmental Science,General Biochemistry, Genetics and Molecular Biology,General Mathematics,Immunology,General Neuroscience

Reference59 articles.

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2. Annamalai L, Bhaskar V, Pauley DR, Knight H, Williams K, Lentz M, Ratai E, Westmoreland SV, González RG, O’Neil SP (2010) Impact of short-term combined antiretroviral therapy on brain virus burden in simian immunodeficiency virus-infected and cd8+ lymphocyte-depleted rhesus macaques. Am J Pathol 177(2):777–791. https://doi.org/10.2353/ajpath.2010.091248

3. Asahchop EL, Meziane O, Mamik MK, Chan WF, Branton WG, Resch L, Gill MJ, Haddad E, Guimond JV, Wainberg MA, Baker GB, Cohen EA, Power C (2017) Reduced antiretroviral drug efficacy and concentration in hiv-infected microglia contributes to viral persistence in brain. Retrovirology. https://doi.org/10.1186/s12977-017-0370-5

4. Askew K, Li K, Olmos-Alonso A, Garcia-Moreno F, Liang Y, Richardson P, Tipton T, Chapman MA, Riecken K, Beccari S, Sierra A, Molnár Z, Cragg MS, Garaschuk O, Perry VH, Gomez-Nicola D (2017) Coupled proliferation and apoptosis maintain the rapid turnover of microglia in the adult brain. Cell Rep 18(2):391–405. https://doi.org/10.1016/j.celrep.2016.12.041

5. Avalos CR, Price SL, Forsyth ER, Pin JN, Shirk EN, Bullock BT, Queen SE, Li M, Gellerup D, O’Connor SL, Zink MC, Mankowski JL, Gama L, Clements JE (2016) Quantitation of productively infected monocytes and macrophages of simian immunodeficiency virus-infected macaques. J Virol 90(12):5643–5656. https://doi.org/10.1128/JVI.00290-16

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