Structure-function relationships in insulin-Reference-Cited by-同舟云学术

Structure-function relationships in insulin

Published:1981-06-01 Issue:6 Volume:1 Page:485-495
ISSN:0144-8463
Container-title:Bioscience Reports
language:en
Short-container-title:

Author:

Saunders D. J.¹

Affiliation:

1. Deutsches Wollforschungsinstitut, Veltmanplatz 8, D-5100 Aachen, F.R.G.

Abstract

A new interpretation of structure-function relationships in the insulin molecule is presented. Negative cooperativity is postulated to arise from a dimerization event occurring between two receptor-bound molecules. The receptor-binding surface of insulin can necessarily not involve residues involved in dimerization as has been generally accepted. Support for this interpretation is based on published data.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Link

https://portlandpress.com/bioscirep/article-pdf/1/6/485/469299/bsr0010485.pdf

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