Selective Signal Capture from Multidimensional GPCR Outputs with Biased Agonists: Progress Towards Novel Drug Development
Author:
Funder
National Heart, Lung, and Blood Institute
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology,Genetics,Molecular Medicine,General Medicine
Link
https://link.springer.com/content/pdf/10.1007/s40291-022-00592-4.pdf
Reference56 articles.
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3. Kenakin TP. The quantification of relative efficacy of agonists. J Pharmacol Methods. 1985;13(4):281–308.
4. Eason MG, Liggett SB. Identification of a Gs coupling domain in the amino-terminus of the third intracellular loop of the a2A-adrenergic receptor: evidence for distinct structural determinants that confer Gs versus Gi coupling. J Biol Chem. 1995;1995(270):24753–60.
5. Eason MG, Jacinto MT, Liggett SB. Contribution of ligand structure to activation of a2AR subtype coupling to Gs. Mol Pharmacol. 1994;1994(45):696–702.
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