A Nonhuman Primate PET Study: Measurement of Brain PDE4 Occupancy by Roflumilast Using (R)-[11C]Rolipram
Author:
Funder
Karolinska Institute
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology
Link
http://link.springer.com/article/10.1007/s11307-018-1168-0/fulltext.html
Reference36 articles.
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2. Tenor H, Hatzelmann A, Church MK, Schudt C, Shute JK (1996) Effects of theophylline and rolipram on leukotriene C4 (LTC4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects. Br J Pharmacol 118(7):1727–1735. https://doi.org/10.1111/j.1476-5381.1996.tb15598.x
3. Giembycz MA, Field SK (2010) Roflumilast: first phosphodiesterase 4 inhibitor approved for treatment of COPD. Drug Des Devel Ther 4:147–158
4. Harrison C (2013) Trial watch: PDE4 inhibitor leads wave of target-specific oral psoriasis drugs. Nat Rev Drug Discov 12(5):335. https://doi.org/10.1038/nrd4017
5. Schafer PH, Day RM (2013) Novel systemic drugs for psoriasis: mechanism of action for apremilast, a specific inhibitor of PDE4. J Am Acad Dermatol 68(6):1041–1042. https://doi.org/10.1016/j.jaad.2012.10.064
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