Prodrugs in cancer chemotherapy
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology,General Medicine,Pathology and Forensic Medicine
Link
http://link.springer.com/content/pdf/10.1007/BF02904292.pdf
Reference101 articles.
1. Knox RJ, Friedlos F, Marchbank T and Roberts JJ: Bioactivation of CB 1954: reaction of the active 4-hydroxylamino derivative with thioesters to form the ultimate DNA- DNA interstrand crosslinking species. Biochem Pharmacol 42:1691–1697, 1991.
2. Knox RJ, Friedlos F and Boland MP: The bioactivation of CB 1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT). Cancer Metastasis Rev 12:195–212, 1993.
3. Roberts JJ, Friedlos F and Knox RJ: CB 1954 (2,4-dinitro-5- aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumor cells. Biochem Biophys Res Commun 140:1073–1078, 1986.
4. Cobb LM, Connors TA, Elson LA, et al: 2,4-dinitro-5-ethyl- eneiminobenzamide (CB 1954): a potent and selective inhibitor of the growth of the Walker carcinoma 256. Biochem Pharmacol 18:1519–1527, 1969.
5. Connors TA and Melzack DH: Studies on the mechanism of action of 5-aziridinyl-2,4-dinitrobenzamide (CB 1954), a selective inhibitor of the Walker tumor. Int J Cancer 7:86–92, 1971.
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