Detection and Quantitation of Afucosylated N-Linked Oligosaccharides in Recombinant Monoclonal Antibodies Using Enzymatic Digestion and LC-MS
Author:
Affiliation:
1. Merck Research Laboratories, 1011 Morris Ave, 07083, Union, NJ, USA
Publisher
American Chemical Society (ACS)
Subject
Spectroscopy,Structural Biology
Link
http://link.springer.com/content/pdf/10.1007/s13361-012-0397-8.pdf
Reference38 articles.
1. IgG-Fc-mediated effector functions: molecular definition of interaction sites for effector ligands and the role of glycosylation
2. Antibody therapeutics:
3. Terminal sugars of Fc glycans influence antibody effector functions of IgGs
4. Impact of Differential Glycosylation on IgG Activity
5. Fucose Depletion from Human IgG1 Oligosaccharide Enhances Binding Enthalpy and Association Rate Between IgG1 and FcγRIIIa
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1. Collision induced unfolding detects subtle differences in intact antibody glycoforms and associated fragments;International Journal of Mass Spectrometry;2018-02
2. Afucosylated Biosimilars need Afucosylation Specific Assays;MOJ Cell Science & Report;2017-11-30
3. Orthogonal liquid chromatography–mass spectrometry methods for the comprehensive characterization of therapeutic glycoproteins, from released glycans to intact protein level;Journal of Chromatography A;2017-05
4. General solutions to decompose heterogeneous compositions using antibody afucosylation as a model system;Biotechnology Progress;2017-01-10
5. The Application of Mass Spectrometry for the Characterization of Monoclonal Antibody-Based Therapeutics;Analysis of Protein Post-Translational Modifications by Mass Spectrometry;2016-10-18
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