Inhibiting and Remodeling Toxic Amyloid-Beta Oligomer Formation Using a Computationally Designed Drug Molecule That Targets Alzheimer’s Disease-Reference-Cited by-同舟云学术

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Inhibiting and Remodeling Toxic Amyloid-Beta Oligomer Formation Using a Computationally Designed Drug Molecule That Targets Alzheimer’s Disease

Published:2018-04-30 Issue:1 Volume:30 Page:85-93
ISSN:1044-0305
Container-title:Journal of the American Society for Mass Spectrometry
language:en
Short-container-title:J. Am. Soc. Mass Spectrom.

Author:

Downey Matthew A.¹,Giammona Maxwell J.¹,Lang Christian A.²,Buratto Steven K.¹,Singh Ambuj²³,Bowers Michael T.¹

Affiliation:

1. Department of Chemistry and Biochemistry, University of California, 93106, Santa Barbara, CA, USA

2. Acelot, Inc., 5385 Hollister Ave, Suite 111, 93111, Santa Barbara, CA, USA

3. Department of Computer Science, University of California, 93106, Santa Barbara, CA, USA

Funder

National Institute on Aging

Army Research Laboratory

Publisher

American Chemical Society (ACS)

Subject

Spectroscopy,Structural Biology

Link

http://link.springer.com/article/10.1007/s13361-018-1975-1/fulltext.html

Reference63 articles.

1. 2017 Alzheimer’s disease facts and figures. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association 13 (4), 325–373

2. Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

3. Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP

4. Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice

5. Amyloid β-peptide is produced by cultured cells during normal metabolism

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1. Computationally Designed Molecules Modulate ALS-Related Amyloidogenic TDP-43_307–319 Aggregation;ACS Chemical Neuroscience;2023-12-05

2. Computationally Designed Small Molecules Disassemble Both Soluble Oligomers and Protofibrils of Amyloid β-Protein Responsible for Alzheimer’s Disease;ACS Chemical Neuroscience;2023-07-13

3. Using mass spectrometry‐based methods to understand amyloid formation and inhibition of alpha‐synuclein and amyloid beta;Mass Spectrometry Reviews;2022-10-12

4. The influences of cholesterol and AC0107 inhibitor molecules on the amyloid-beta fibrils aggregation in cell membranes: molecular modeling approach;The European Physical Journal Plus;2022-04

5. Structural Proteomics Methods to Interrogate the Conformations and Dynamics of Intrinsically Disordered Proteins;Frontiers in Chemistry;2021-03-11

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