Native MS and ECD Characterization of a Fab–Antigen Complex May Facilitate Crystallization for X-ray Diffraction-Reference-Cited by-同舟云学术

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Native MS and ECD Characterization of a Fab–Antigen Complex May Facilitate Crystallization for X-ray Diffraction

Published:2016-04-21 Issue:7 Volume:27 Page:1139-1142
ISSN:1044-0305
Container-title:Journal of the American Society for Mass Spectrometry
language:en
Short-container-title:J. Am. Soc. Mass Spectrom.

Author:

Zhang Ying¹²,Cui Weidong¹,Wecksler Aaron T.³,Zhang Hao¹,Molina Patricia³,Deperalta Galahad³,Gross Michael L.¹

Affiliation:

1. Department of Chemistry, Washington University in St. Louis, One Brookings Dr., 63130, St. Louis, MO, USA

2. Analytical Research and Development, Pfizer Inc., 63017, Chesterfield, MO, USA

3. Protein Analytical Chemistry, Genentech, a Member of the Roche Group, 94080, South San Francisco, CA, USA

Funder

National Institutes of Health

Publisher

American Chemical Society (ACS)

Subject

Spectroscopy,Structural Biology

Link

http://link.springer.com/content/pdf/10.1007/s13361-016-1398-9.pdf

Reference38 articles.

1. Lundblad, R.L.: Introduction to biopharmaceutical conformational analysis. In: Approaches to the conformational analysis of biopharmaceuticals; Chapman and Hall/CRC: pp. 1–18 (2009)

2. Razinkov, V.I., Treuheit, M.J., Becker, G.W.: Methods of high throughput biophysical characterization in biopharmaceutical development. Curr. Drug Discov. Technol. 10, 59–70 (2013)

3. Das, T.K.: Biophysical methods for biotherapeutics: Discovery and development applications; John Wiley and Sons, Inc. (2014)

4. Beck, A., Sanglier-Cianferani, S., Van Dorsselaer, A.: Biosimilar, biobetter, and next generation antibody characterization by mass spectrometry. Anal. Chem. 84, 4637–4646 (2012)

5. Zhang, Z., Pan, H., Chen, X.: Mass spectrometry for structural characterization of therapeutic antibodies. Mass Spectrom. Rev. 28, 147–176 (2009)

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