Hydrogen-Deuterium Exchange and Hydroxyl Radical Footprinting for Mapping Hydrophobic Interactions of Human Bromodomain with a Small Molecule Inhibitor-Reference-Cited by-同舟云学术

Hydrogen-Deuterium Exchange and Hydroxyl Radical Footprinting for Mapping Hydrophobic Interactions of Human Bromodomain with a Small Molecule Inhibitor

Published:2019-11-12 Issue:12 Volume:30 Page:2795-2804
ISSN:1044-0305
Container-title:Journal of the American Society for Mass Spectrometry
language:en
Short-container-title:J. Am. Soc. Mass Spectrom.

Author:

Li Ke Sherry¹,Schaper Bergman Elizabeth T.¹,Beno Brett R.²,Huang Richard Y.-C.³,Deyanova Ekaterina³,Chen Guodong³,Gross Michael L.¹

Affiliation:

1. Department of Chemistry, Washington University, 63130, St. Louis, MO, USA

2. Molecular Structure & Design, Research and Development, Bristol-Myers Squibb, 08540, Princeton, NJ, USA

3. Pharmaceutical Candidate Optimization, Research and Development, Bristol-Myers Squibb, 08540, Princeton, NJ, USA

Funder

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Spectroscopy,Structural Biology

Link

http://link.springer.com/content/pdf/10.1007/s13361-019-02316-1.pdf

Reference35 articles.

1. Cohen, Y.: Small Molecules: the Silent Majority of Pharmaceutical Pipelines. (2015)

2. An overview of hydrogen deuterium exchange mass spectrometry (HDX-MS) in drug discovery

3. Applications of Hydrogen/Deuterium Exchange MS from 2012 to 2014

4. Analysis of Protein Conformation and Dynamics by Hydrogen/Deuterium Exchange MS

5. Conformational Assessment of Adnectin and Adnectin-Drug Conjugate by Hydrogen/Deuterium Exchange Mass Spectrometry

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