A Case Study to Identify the Drug Conjugation Site of a Site-Specific Antibody-Drug-Conjugate Using Middle-Down Mass Spectrometry-Reference-Cited by-同舟云学术

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A Case Study to Identify the Drug Conjugation Site of a Site-Specific Antibody-Drug-Conjugate Using Middle-Down Mass Spectrometry

Published:2019-08-19 Issue:11 Volume:30 Page:2419-2429
ISSN:1044-0305
Container-title:Journal of the American Society for Mass Spectrometry
language:en
Short-container-title:J. Am. Soc. Mass Spectrom.

Author:

Hernandez-Alba Oscar¹,Houel Stéphane²,Hessmann Steve¹,Erb Stéphane¹,Rabuka David³,Huguet Romain²,Josephs Jonathan²,Beck Alain⁴,Drake Penelope M.³,Cianférani Sarah¹

Affiliation:

1. Laboratoire de Spectrométrie de Masse BioOrganique, CNRS IPHC UMR 7178, Université de Strasbourg, ECPM R5-0 – 25 Rue Becquerel, Cedex 2, 67087, Strasbourg, France

2. Thermo Fisher Scientific, 355 River Oaks Pkwy, 95134, San Jose, CA, USA

3. Catalent Biologics West, 5703 Hollis Street, Emeryville, 94530, CA, USA

4. IRPF, Centre d’Immunologie Pierre-Fabre (CIPF), Saint-Julien-en-Genevois, France

Funder

Agence Nationale de la Recherche

Publisher

American Chemical Society (ACS)

Subject

Spectroscopy,Structural Biology

Link

http://link.springer.com/content/pdf/10.1007/s13361-019-02296-2.pdf

Reference39 articles.

1. Next generation antibody drugs: pursuit of the 'high-hanging fruit'

2. Strategies and challenges for the next generation of antibody–drug conjugates

3. Cutting-edge mass spectrometry methods for the multi-level structural characterization of antibody-drug conjugates

4. Mass spectrometry for structural characterization of therapeutic antibodies

5. An improved trypsin digestion method minimizes digestion-induced modifications on proteins

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3. Enhanced Characterization of Lysine-Linked Antibody Drug Conjugates Enabled by Middle-Down Mass Spectrometry and Higher-Energy Collisional Dissociation-Triggered Electron-Transfer/Higher-Energy Collisional Dissociation and Ultraviolet Photodissociation;Antibodies;2024-04-17

4. Internal Fragments Enhance Middle-Down Mass Spectrometry Structural Characterization of Monoclonal Antibodies and Antibody-Drug Conjugates;Analytical Chemistry;2024-01-31

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