Identifying Secondary Mutations in Chinese Patients with Imatinib-Resistant Gastrointestinal Stromal Tumors (GISTs) by Next Generation Sequencing (NGS)

Author:

Du Jiang,Wang Si,Wang Rui,Wang Si-Yao,Han Qiang,Xu Hong-Tao,Yang Peng,Liu Yang

Funder

Natural Science Foundation of Liaoning Province

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,General Medicine,Pathology and Forensic Medicine

Reference58 articles.

1. Di Vita M, Zanghì A, Cavallaro A et al (2019) Gastric GIST and prognostic models. Which is the best to predict survival after surgery? Ann Ital Chir 90:31–40

2. Kalfusová A, Kodet R (2017) Molecular mechanisms of primary and secondary resistance, molecular-genetic features and characteristics of KIT/PDGFRA non-mutated GISTs. Cesk Patol 53(4):167–173

3. Miettinen M, Monihan JM, Sarlomo-Rikala M et al (1999) Gastrointestinal stromal tumors/smooth muscle tumors (GISTs) primary in the omentum and mesentery: clinicopathologic and immunohistochemical study of 26 cases. Am J Surg Pathol 23(9):1109–1118

4. Li J (2016) Molecular mechanism of gastrointestinal stromal tumors and progress in drug research. Zhonghua Wei Chang Wai Ke Za Zhi 19(11):1316–1320

5. Corless CL, Schroeder A, Griffith D et al (2005) PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib. J Clin Oncol 23(23):5357–5364

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