Early Start of Oral Clarithromycin Is Associated with Better Outcome in COVID-19 of Moderate Severity: The ACHIEVE Open-Label Single-Arm Trial

Author:

Tsiakos Konstantinos,Tsakiris Antonios,Tsibris Georgios,Voutsinas Pantazis-Michael,Panagopoulos Periklis,Kosmidou Maria,Petrakis Vasileios,Gravvani Areti,Gkavogianni Theologia,Klouras Eleftherios,Katrini Konstantina,Koufargyris Panagiotis,Rapti Iro,Karageorgos Athanassios,Vrentzos Emmanouil,Damoulari Christina,Zarkada Vagia,Sidiropoulou Chrysanthi,Artemi Sofia,Ioannidis Anastasios,Papapostolou Androniki,Michelakis Evangelos,Georgiopoulou Maria,Myrodia Dimitra-Melia,Tsiamalos Panteleimon,Syrigos Konstantinos,Chrysos George,Nitsotolis Thomas,Milionis Haralampos,Poulakou Garyphallia,Giamarellos-Bourboulis Evangelos J.ORCID

Funder

abbott operation products ag

Publisher

Springer Science and Business Media LLC

Subject

Infectious Diseases,Microbiology (medical)

Reference24 articles.

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2. Gautret P, Lagier JC, Parola P, Hoang VT, Meddeb L, Mailhe M, Doudier B, Courjon J, Giordanengo V, Vieira VE, Tissot Dupont H, Honoré S, Colson P, Chabrière E, La Scola B, Rolain JM, Brouqui P, Raoult D. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int J Antimicrob Agents. 2020;56:105949.

3. Metlay JP, Waterer GW, Long AC, Anzueto A, Brozek J, Crothers K, Cooley LA, Dean NC, Fine MJ, Flanders SA, Griffin MR, Metersky ML, Musher DM, Restrepo MI, Whitney CG. Diagnosis and treatment of adults with community-acquired pneumonia. Am J Resp Crit Care Med. 2019;200:45–67.

4. García Vázquez E, Mensa J, Martínez JA, Marcos MA, Puig J, Ortega M, Torres A. Lower mortality among patients with community-acquired pneumonia treated with a macrolide plus a beta-lactam agent versus a beta-lactam agent alone. Eur J Clin Microbiol Infect Dis. 2005;24:190–5.

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