Adverse Reactions in a Phase 1 Trial of the Anti-Malarial DM1157: An Example of Pharmacokinetic Modeling and Simulation Guiding Clinical Trial Decisions-Reference-Cited by-同舟云学术

Adverse Reactions in a Phase 1 Trial of the Anti-Malarial DM1157: An Example of Pharmacokinetic Modeling and Simulation Guiding Clinical Trial Decisions

Published:2022-02-20 Issue:2 Volume:11 Page:841-852
ISSN:2193-8229
Container-title:Infectious Diseases and Therapy
language:en
Short-container-title:Infect Dis Ther

Author:

Balevic Stephen J.^ORCID,Raja Shruti M.,Randell Rachel,Deye Gregory A.,Conrad Thomas,Nakamura Aya,Peyton David H.,Shotwell Sandra,Liebman Katherine,Cohen-Wolkowiez Michael,Guptill Jeffrey T.

Funder

Foundation for the National Institutes of Health

Publisher

Springer Science and Business Media LLC

Subject

Infectious Diseases,Microbiology (medical)

Link

https://link.springer.com/content/pdf/10.1007/s40121-022-00605-z.pdf

Reference10 articles.

1. World Health Organization (WHO). World Malaria Report 2019. WHO web site. https://www.who.int/publications/i/item/9789241565721. Accessed 3 Nov 2020.

2. Coronado LM, Nadovich CT, Spadafora C. Malarial hemozoin: from target to tool. Biochim Biophys Acta. 2014;1840:2032–41. https://doi.org/10.1016/j.bbagen.2014.02.009.

3. Mzayek F, Deng H, Mather FJ, et al. Randomized dose-ranging controlled trial of AQ-13, a candidate antimalarial, and chloroquine in healthy volunteers. PLoS Clin Trials. 2007;2(1):e6. https://doi.org/10.1371/journal.pctr.0020006.

4. Phillips-Howard PA, West LJ. Serious adverse drug reactions to pyrimethamine-sulphadoxine, pyrimethamine-dapsone and to amodiaquine in Britain. J R Soc Med. 1990;83(2):82–5. https://doi.org/10.1177/014107689008300208.

5. Wielgo-Polanin R, Lagarce L, Gautron E, et al. Hepatotoxicity associated with the use of a fixed combination of chloroquine and proguanil. Int J Antimicrob Agents. 2005;26(2):176–8. https://doi.org/10.1016/j.ijantimicag.2005.04.019.

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