Continuous flow production in the final step of vortioxetine synthesis. Piperazine ring formation on a flow platform with a focus on productivity and scalability
Author:
Publisher
Springer Science and Business Media LLC
Subject
Organic Chemistry,Fluid Flow and Transfer Processes,Chemistry (miscellaneous)
Link
http://link.springer.com/content/pdf/10.1007/s41981-019-00036-x.pdf
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3. Sanchez C, Asin KE, Artigas F (2015) Vortioxetine, a novel antidepressant with multimodal activity: review of preclinical and clinical data. Pharmacol Ther 145:43–57
4. Bang-Andersen B, Ruhland T, Jorgensen M, Smith G, Frederiksen K, Jensen KG, Zhong H, Nielsen SM, Hogg S, Mork A, Stensbol TB (2011) Discovery of 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. J Med Chem 54:3206–3221
5. Gibb A, Deeks ED (2014) Vortioxetine: first global approval. Drugs 74:135–145
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