Abstract
AbstractContinuous flow chemistry holds great potential for the production of biologically relevant molecules. Herein, we present an approach for the continuous synthesis of cannabidiol and tetrahydrocannabinol in a one-flow system. The designed route consists of a reaction cascade involving Friedel-Crafts alkylation, subsequent ring opening and cyclisation in up to 45% yield. The reactions were successfully performed using both hetero- and homogeneous Lewis acids in continuous flow and provide yields that are similar to comparable batch processes.
Graphical abstract
Funder
H2020 European Research Council
Publisher
Springer Science and Business Media LLC
Subject
Organic Chemistry,Fluid Flow and Transfer Processes,Chemistry (miscellaneous)
Cited by
4 articles.
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