Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis

Author:

Chai Ming G.,Tu Quyen,Cotta Menino O.,Bauer Michelle J.,Balch Ross,Okafor Charles,Comans Tracy,Kruger Peter,Meyer Jason,Shekar Kiran,Brady Kara,Fourie Cheryl,Sharp Natalie,Vlad Luminita,Whiley David,Ungerer Jacobus P. J.,Mcwhinney Brett C.,Farkas Andras,Paterson David L.,Clark Julia E.,Hajkowicz Krispin,Raman Sainath,Bialasiewicz Seweryn,Lipman Jeffrey,Forde Brian M.,Harris Patrick N. A.,Schlapbach Luregn J.,Coin Lachlan,Roberts Jason A.,Irwin Adam D.ORCID

Funder

National Health and Medical Research Council

The University of Queensland

Publisher

Springer Science and Business Media LLC

Reference40 articles.

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2. Schlapbach LJ, Straney L, Alexander J, MacLaren G, Festa M, Schibler A, Slater A, Group APS (2015) Mortality related to invasive infections, sepsis, and septic shock in critically ill children in Australia and New Zealand, 2002–13: a multicentre retrospective cohort study. Lancet Infect Dis 15:46–54. https://doi.org/10.1016/S1473-3099(14)71003-5

3. Kumar A, Haery C, Paladugu B, Kumar A, Symeoneides S, Taiberg L, Osman J, Trenholme G, Opal SM, Goldfarb R, Parrillo JE (2006) The duration of hypotension before the initiation of antibiotic treatment is a critical determinant of survival in a murine model of Escherichia coli septic shock: association with serum lactate and inflammatory cytokine levels. J Infect Dis 193:251–258. https://doi.org/10.1086/498909

4. Evans IVR, Phillips GS, Alpern ER, Angus DC, Friedrich ME, Kissoon N, Lemeshow S, Levy MM, Parker MM, Terry KM, Watson RS, Weiss SL, Zimmerman J, Seymour CW (2018) Association between the New York sepsis care mandate and in-hospital mortality for pediatric sepsis. JAMA 320:358–367. https://doi.org/10.1001/jama.2018.9071

5. Tabak YP, Vankeepuram L, Ye G, Jeffers K, Gupta V, Murray PR (2018) Blood culture turnaround time in U.S. acute care hospitals and implications for laboratory process optimization. J Clin Microbiol. https://doi.org/10.1128/jcm.00500-18

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