The relationship between adrenocortical candidate gene expression and clinical response to hydrocortisone in patients with septic shock

Author:

Cohen JeremyORCID,Blumenthal Antje,Cuellar-Partida Gabriel,Evans David M.,Finfer Simon,Li Qiang,Ljungberg Johanna,Myburgh John,Peach Elizabeth,Powell Joseph,Rajbhandari Dorrilyn,Rhodes Andrew,Senabouth Anne,Venkatesh Balasubramanian

Funder

National Health and Medical Research Council

Publisher

Springer Science and Business Media LLC

Subject

Critical Care and Intensive Care Medicine

Reference28 articles.

1. Venkatesh B, Finfer S, Cohen J, Rajbhandari D, Arabi Y, Bellomo R, Billot L, Correa M, Glass P, Harward M, Joyce C, Li Q, McArthur C, Perner A, Rhodes A, Thompson K, Webb S, Myburgh J, Investigators AT, Group tANZICSCT (2018) Adjunctive glucocorticoid therapy in patients with septic shock. N Engl J Med 378:797–808

2. Annane D, Renault A, Brun-Buisson C, Megarbane B, Quenot JP, Siami S, Cariou A, Forceville X, Schwebel C, Martin C, Timsit JF, Misset B, Ali Benali M, Colin G, Souweine B, Asehnoune K, Mercier E, Chimot L, Charpentier C, Francois B, Boulain T, Petitpas F, Constantin JM, Dhonneur G, Baudin F, Combes A, Bohe J, Loriferne JF, Amathieu R, Cook F, Slama M, Leroy O, Capellier G, Dargent A, Hissem T, Maxime V, Bellissant E, Network C-T (2018) Hydrocortisone plus fludrocortisone for adults with septic shock. N Engl J Med 378:809–818

3. Venkatesh B, Cohen J (2011) Adrenocortical (dys)function in septic shock: a sick euadrenal state. Best Pract Res Clin Endocrinol Metab 25:719–733

4. Cohen J, Bellomo R, Billot L, Burrell LM, Evans DM, Finfer S, Hammond NE, Li Q, Liu D, McArthur C, McWhinney B, Moore J, Myburgh J, Peake S, Pretorius C, Rajbhandari D, Rhodes A, Saxena M, Ungerer JPJ, Young MJ, Venkatesh B (2020) Plasma cortisol, aldosterone, and ascorbic acid concentrations in patients with septic shock do not predict treatment effect of hydrocortisone on mortality. a nested cohort study. Am J Respir Crit Care Med 202:700–707

5. Ledderose C, Mohnle P, Limbeck E, Schutz S, Weis F, Rink J, Briegel J, Kreth S (2012) Corticosteroid resistance in sepsis is influenced by microRNA-124–induced downregulation of glucocorticoid receptor-alpha. Crit Care Med 40:2745–2753

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